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through imputation of SNP data to a common reference panel. In contrast, the risk-profiling method requires individual level genetic and environmental measures in only the target sample with the GRPS constructed based on GWAS summary statistics from a top trading and contracting companies in qatar independent discovery sample that is (most likely) ignorant of the environmental conditions.

In the risk-profiling framework, identification of true interaction effects largely depends on the prediction accuracy of the genetic and environmental factors.

Combined efforts in the psychiatric genetics community (PGC) have achieved 34 241 schizophrenia cases, and 45 604 controls in 2014 (2014) resulting in high precision of the estimation of individual SNP effects and consequently large prediction accuracy of the GRPS. Precision of the environmental measures largely depends on the measure of interest.

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